Cervantes contra Lope is a TV movie portraying the confrontation at the beginning of the 17th century between two of European literature’s most famous writers, Miguel de Cervantes and Félix Lope de Vega. The subject is treated as a documentary. A TV crew from the 21st century is sent to Madrid in 1614 to interview Cervantes, Lope and people from their circle. The Quijote de Avellaneda has just been published and a bitter quarrel has broken out between the two literary geniuses. The documentary looks at the intrigue surrounding the identity of Avellaneda, while showing Cervantes and Lope as two brilliant individuals plagued with self-doubt and feelings of failure.